Ventilator-induced lung injury, cytokines, PEEP, and mortality: implications...
AbstractA mainstay in the supportive care of patients with acute lung injury (ALI)/acute respiratory distress syndrome (ARDS) is mechanical ventilation. However, a number of animal and clinical studies...
View ArticleAssessment of patient–ventilator breath contribution during neurally adjusted...
AbstractPurposeDuring neurally adjusted ventilatory assist (NAVA), it is difficult to quantify the relative contribution of the patient versus the ventilator to the inspiratory tidal volume (Vtinsp)....
View ArticleNeuroventilatory efficiency and extubation readiness in critically ill patients
AbstractIntroductionBased on the hypothesis that failure of weaning from mechanical ventilation is caused by respiratory demand exceeding the capacity of the respiratory muscles, we evaluated whether...
View ArticleEffects of anesthetic regimes on inflammatory responses in a rat model of...
AbstractPurposeGamma-aminobutyric acid (GABA) is the major inhibitory neurotransmitter through activation of GABA receptors. Volatile anesthetics activate type-A (GABAA) receptors resulting in...
View ArticleThe Berlin definition of ARDS: an expanded rationale, justification, and...
AbstractPurposeOur objective was to revise the definition of acute respiratory distress syndrome (ARDS) using a conceptual model incorporating reliability and validity, and a novel iterative approach...
View ArticleYear in review 2011: Critical Care - respirology
AbstractManagement of acute respiratory failure is an important component of intensive care. In this review, we analyze 21 original research articles published last year in Critical Care in the field...
View ArticleNovel approaches to minimize ventilator-induced lung injury
AbstractDespite over 40 years of research, there is no specific lung-directed therapy for the acute respiratory distress syndrome (ARDS). Although much has evolved in our understanding of its...
View ArticleLower tidal volume strategy (≈3 ml/kg) combined with extracorporeal CO 2...
AbstractBackgroundAcute respiratory distress syndrome is characterized by damage to the lung caused by various insults, including ventilation itself, and tidal hyperinflation can lead to ventilator...
View ArticleYear in review 2012: Critical Care - respirology
AbstractAcute respiratory failure is a dominant feature of critical illness. In this review, we discuss 17 studies published last year in Critical Care. The discussion focuses on articles on several...
View ArticleLung protection during non-invasive synchronized assist versus volume control...
AbstractIntroductionExperimental work provides insight into potential lung protective strategies. The objective of this study was to evaluate markers of ventilator-induced lung injury after two...
View ArticleMonocyte interaction accelerates HCl-induced lung epithelial remodeling
AbstractBackgroundAcute respiratory distress syndrome (ARDS) is characterized by overwhelming inflammatory responses and lung remodeling. We hypothesized that leukocyte infiltration during the...
View ArticleYear in review 2013: Critical Care - respirology
AbstractThis review documents important progress made in 2013 in the field of critical care respirology, in particular with regard to acute respiratory failure and acute respiratory distress syndrome....
View ArticleEarly activation of pro-fibrotic WNT5A in sepsis-induced acute lung injury
AbstractIntroductionThe mechanisms of lung repair and fibrosis in the acute respiratory distress syndrome (ARDS) are poorly known. Since the role of WNT/β-catenin signaling appears to be central to...
View ArticleAssessment of patient-ventilator breath contribution during neurally adjusted...
AbstractIntroductionWe previously showed in animals that the ratio of inspired tidal volume (Vtinsp) to inspiratory peak electrical activity of the diaphragm (EAdipk) can be used to quantify the...
View ArticleTryptase is involved in the development of early ventilator-induced pulmonary...
AbstractIntroductionMost patients with sepsis and acute lung injury require mechanical ventilation to improve oxygenation and facilitate organ repair. Mast cells are important in response to infection...
View ArticleFeasibility of neurally adjusted positive end-expiratory pressure in rabbits...
AbstractBackgroundDuring conventional Neurally Adjusted Ventilatory Assist (NAVA), the electrical activity of the diaphragm (EAdi) is used for triggering and cycling-off inspiratory assist, with a...
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